Just to add to what Ray said, most of them have about 1/2" of space behind them, but I would not recommend using a screw to remove them. A better way to get them out is to get a drift punch about 1/4" in diameter, measure it exactly with calipers, then use a drill exactly that size (or a few thousandths bigger)on the center of the old freeze plug. The drill will definitely move in noticeably when it cuts through the plug, so you won't have to worry much about cutting into the block.
Then insert the drift punch about 1/4" into the hole in the freeze plug and tilt the freeze plug out. If it doesn't come with just hand pressure, tap the punch on the side with a hammer to tilt the plug. Works every time.
NAPA has a full line of freeze plugs of various sizes. When driving the replacement in, first be sure the hole and the seat for the plug are clean and rust/burr free, then coat both plug and hole liberally with "Kopper Coat" sealer or equivalent, and drive in place by driving lightly around the edges. Once it is bottomed out, use the same punch to dish in the center of the plug and expand it into the socket for a tight fit.
Hope that helps! Good luck with the repair.
All the Best, Chip
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"It's wise to choose a SIX"